Symbol
Name
ID

Rac1
Rac family small GTPase 1
MGI:97845

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Echogenic intracardiac focus	Ventricular septal defect	Bicuspid aortic valve	Patent ductus arteriosus
Disease(s) Associated with RAC1
autosomal dominant intellectual developmental disorder 48

Mouse Phenotypes

abnormal myocardium layer morphology

abnormal myocardial fiber morphology

abnormal trabecula carnea morphology

trabecula carnea hypoplasia

abnormal myocardium compact layer morphology

thin myocardium compact layer

thin ventricle myocardium compact layer

thin right ventricle myocardium compact layer

abnormal ventricle myocardium morphology

abnormal cardiac outflow tract development

abnormal heart development

abnormal fetal cardiomyocyte morphology

cardia bifida

abnormal heart morphology

double outlet right ventricle

overriding aortic valve

abnormal heart apex morphology

atrial septal defect

abnormal interventricular septum morphology

ventricular septal defect

cardiac hypertrophy

small heart

increased heart left ventricle weight

abnormal heart right ventricle morphology

abnormal interventricular groove morphology

decreased fetal cardiomyocyte proliferation

Availability

Mouse Genotype

Rac1^em1(IMPC)Mbp/Rac1⁺

Rac1^tm1Djk/Rac1^tm1Djk
Tg(Nkx2-5-cre)9Eno/0 (conditional)

Rac1^tm1Djk/Rac1^tm1Djk
Tg(Mef2c-cre)2Blk/0 (conditional)

Rac1^tm1Tyb/Rac1^tm2Tyb
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Rac1^tm1Djk/Rac1^tm1.1Djk
Tg(Myh6-cre/Esr1*)1Liao/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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